姓名：徐绘

职称：副教授

部门：化学与环境工程学院

地址：2号楼204室

Email: hxu@ahpu.edu.cn

学术经历：

2021.12-至今， 化环学院，副教授

2018.06-2021.11， 化环学院，讲师

开设课程：

主要承担《有机化学》、《高等仪器分析》等课程

研究方向：

绿色有机合成、药物中间体合成

获奖情况：

1）校青年教师优秀论文奖（2022一等，2021特等）；

2）校教学骨干（2022三档）

主持项目：

1) 安徽省自然科学基金青年基金项目：卤代试剂促进下螺环吡唑啉的合成及其化学选择性研究（2008085QB64），2020.7−2022.6，主持；

2) 安徽省教育厅重点实验室开放基金项目：可见光催化的多组分反应合成吡唑啉酮螺环化合物（LCECSC-15），2020.10−2022.3，主持；

3)  国基预研项目：基于碘促进的环外α,β-不饱和环酮与烯胺串联反应选择性的调控构建不同类型螺环（Xjky2020079），2020.10−2021.12，主持；

4)  引进人才科研启动基金项目：机械研磨条件下含氮杂环化合物的绿色合成（2018YQQ015），2018.10−2021.9，主持；

5) 横向项目：内酯类香料衍生物制备及在自主调香中的应用，2022.4−2024.1，主持。

6) 横向项目：基于焦甜香韵的新型香料制备及在卷烟中应用研究，2020.9−2022.1，主持。

7) 横向项目：一种奈拉滨中间体的合成工艺开发，2019.12−2020.6，主持；

代表性论文：

1. He, Z.-Y.; Ning, Y.; Zhao, Y.-F.; Diao, H.-L.; Zou, P.*; Wang, W.-B.; Shu, J.-S.*; Xu, H.*, Synthesis of spirocyclopropanes via iodine-promoted bimolecular cyclization of 2-benzylidene 1,3-indandiones. Synth. Commun. 2022, 52, 2322–2333.

2. Xu, H.; Chen, H.; Hu, X.; Xuan, G.; Li, P.*; Zhang, Z.* Synthesis of Fully Substituted 5‑(o‑Hydroxybenzoyl)imidazoles via Iodine-Promoted Domino Reaction of Aurones with Amidines. J. Org. Chem. 2022, 87, 16204–16212.

3. Xu, H.; Li, M.-J.; Chen, H.; Huang, F.-H.; Zhu, Q.-Y.; Wang, G.-W.*; Zhang, Z.* I₂/FeCl₃‑Catalyzed Domino Reaction of Aurones with Enamino Esters for the Synthesis of Highly Functionalized Pyrroles. Org. Lett. 2022, 24, 8406–8411.

4. Xu, H.; Wang, G.-W.* Solvent-Free Mechanosynthesis of Polysubstituted 1,2-Dihydroquinolines from Anilines and Alkyne Esters. J. Org. Chem. 2022, 87, 8480–8491.

5. He, Z.-Y.; Xu, H.*; Wang, W.-B.; Xu, H.-J.; Zou, P.* Iodine-promoted cyclization of alkylidene barbiturates in water: facile synthesis of dihydrofuryl spirobarbiturates. Heterocycles 2022, 104, 952–960. 

6. Chen, H.; Xu, H.*, He, Z.-Y.; Zou, P.; Huang, F.-H.; Jin, Y.*; Zhang, Z.* N-Iodosuccinimide-Promoted Selective Construction of Cyclopropyl and Dihydrofuranyl Spirooxindoles from Alkylidene Oxindoles and Annular β-Dicarbonyl Compounds. Synthesis 2022, 54, 2423–2432.

7. Xu, H.; Hong, R.; Weng, M.-Y.; Huang, R.-L.; Wang, G.-W.*; Zhang, Z.* Regiodivergent Synthesis of 4,5′- and 4,4′-Imidazolinyl Spiropyrazolones from 4‑Alkylidene Pyrazolones and Amidines. Org. Lett. 2021, 23, 5305–5310.

8. Xu, H.; Huang, R.-L.; Shu, Z.; Hong, R.*; Zhang, Z.* Chemoselective synthesis of 5,4′-imidazolinyl spirobarbiturates via NBS-promoted cyclization of unsaturated barbiturates and amidines. Org. Biomol. Chem. 2021, 19, 4978–4985.

9. Weng, M.-Y.; Xu, H.*; Chen, H.; Zhang, Z.* Liquid-assisted mechanosynthesis of trans-2,3-dihydropyrroles from chalcones and enamines. Heterocycle 2021, 102, 114–121.

10. Xu, H.; Yu, F.; Huang, R.; Weng, M. Chen, H.; Zhang, Z.* Synthesis of polysubstituted quinolines through promoter-regulated selective annulation and C–C bond cleavage from 2-styrylanilines and β-keto esters. Org. Chem. Front. 2020, 7, 3368–3373.

11. Xu, H.; Weng, M.-Y.; Chen, H.; Zhang, Z.* Unexpected Iodine-Promoted Aerobic Oxidation of α-Cyano-δ-keto Esters: A Facile Synthesis of α,δ-Dicarbonyl Esters. Synthesis 2020, 52, 1841–1846.

12. Xu, H.; Fan, G.-P.; Liu, Z.; Wang, G.-W.* Catalyst- and solvent-free mechanochemical synthesis of isoxazoles from N-hydroxybenzimidoyl chlorides and enamino carbonyl compounds. Tetrahedron 2018, 74, 6607–6611.

13. Xu, H.; Chen, K.; Liu, H.-W.; Wang, G.-W.* Solvent-free N-iodosuccinimide-promoted synthesis of spiroimidazolines from alkenes and amidines under ball-milling conditions. Org. Chem. Front. 2018, 5, 2864–2869.

14. Xu, H.; Liu, H.-W.; Chen, K.; Wang, G.-W.* One-Pot Multicomponent Mechanosynthesis of Polysubstituted trans-2,3-Dihydropyrroles and Pyrroles from Amines, Alkyne Esters, and Chalcones. J. Org. Chem. 2018, 83, 6035–6049.

15. Xu, H.; Liu, H.-W.; Lin, H.-S.; Wang, G.-W.* Solvent-free iodine-promoted synthesis of 3,2′-pyrrolinyl spirooxindoles from alkylidene oxindoles and enamino esters under ball-milling conditions. Chem. Commun. 2017, 53, 12477–12480.

16. Zeng, J.-C.; Xu, H.*; Zhang, Z.* Manganese (III) acetate mediated synthesis of polysubstituted pyrroles under solvent-free ball milling. Tetrahedron Lett. 2017, 58, 674–678.

17. Xu, H.; Zeng, J.-C.; Wang, F.-J. Zhang, Z.* Metal-Free Synthesis of 2,4,6-Trisubstituted Pyridines via Iodine-Initiated Reaction of Methyl Aryl Ketones with Amines under Neat Heating. Synthesis 2017, 49, 1879–1883.

18. Xu, H.; Wang, F.-J.; Xin, M.; Zhang, Z.* I₂-Promoted Condensation/Cyclization of Aryl Methyl Ketones with Anilines for Facile Synthesis of 1,2,4-Triarylpyrroles. Eur. J. Org. Chem. 2016, 925–929.

19. Li, Y.*; Xu, H.; Xing, M.; Huang, F.; Jia, J.; Gao, J.* Iodine-Promoted Construction of Polysubstituted 2,3-Dihydropyrroles from Chalcones and β‑Enamine Ketones (Esters). Org. Lett. 2015, 17, 3690–3693.

20. Xu, H.; Li, Y.*; Xing, M.; Jia, J.; Han, L.; Ye, Q.; Gao, J.* Synthesis of Pyrroles from β-Enamines and Nitroolefins Catalyzed by I₂ under High-speed Vibration Milling (HSVM). Chem. Lett. 2015, 44, 574–576.